Comparison of Clostridioides difficile Stool Toxin Concentrations in Adults With Symptomatic Infection and Asymptomatic Carriage Using an Ultrasensitive Quantitative Immunoassay Clin Infec Dis 2019. https://doi.org/10.1093/cid/ciy415 クロ…

抗HIV療法の基本は多剤併用（基本的に3剤以上の併用）だが，多剤併用療法でコントロールが良好な患者に対する維持療法としてドルテグラビル(DTG)＋リルピビリン(RPV)やDTG＋ラミブジン(3TC)などの2剤療法の有効性が示されている[1,2]．これらは，HIV治療薬の…

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) Clin Infect Dis. 2018;336:1…

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial Lancet 2018; 391: 668–78 （全文フリー） 読んで字の通りの結果のRCTです． 黄色ブドウ球菌菌血症に対するベ…

Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW Clinical Infectious Diseases, 2018 PMID: 29020373 【背景】Plasmodium knowlesiは東…

Effect of Antibiotic Prophylaxis on Surgical Site Infections Following Removal of Orthopedic Implants Used for Treatment of Foot, Ankle, and Lower Leg Fractures A Randomized Clinical Trial JAMA. 2017;318(24):2438-2445. PMID: 29279933 【目…

Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials Lancet Infec Dis. 2018 Jan;18(1):108-120. PMID: 29102324 【背景】 βラクタム…

Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort Clinical Infectious Diseases, Volume 66, Issue 2, 6 Jan…